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Grignol, G., Eddington, D., Karle, D., and Rickloff, J., “Chemical and Biological Aspects of Hydrogen Peroxide Gas”
Proceedings of ISPE Barrier Isolation Technology Conference, Arlington, VA, June 5-6, 2000.

The interactions of hydrogen peroxide concentrations and surface temperatures were studied in an isolator using chemical and microbiological techniques. These tests verified commonly accepted theories of the gaseous properties of flash vaporized hydrogen peroxide which have recently been challenged.


Rickloff, J.R., “Key Aspects of Validating Hydrogen Peroxide Gas Cycles in Isolator Systems”
Journal of Validation Technology, 5:61-71, 1998.

The purpose of this paper was to revisit some essential validation aspects of sanitizing isolators with hydrogen peroxide gas in order to assist the industry in demonstrating reproducibility of the process under worst-case conditions.



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